Multiple endocrine neoplasia type 2 (MEN2) is an inherited disorder in which one or more of the endocrine glands are overactive or form a tumor. Endocrine glands most commonly involved include:
MEN2 is caused by a defect in the RET
MEN2 is divided into three subtypes: type 2A, type 2B, and
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|Medullary thyroid carcinoma||0002865|
|30%-79% of people have these symptoms|
Excessive, persistent worry and fear
|Elevated urinary epinephrine||0003639|
|Elevated urinary norepinephrine||0003345|
|Elevated urinary vanillylmandelic acid||0011978|
Sweating, increased[ more ]
Missed heart beat
Skipped heart beat[ more ]
Enlarged parathyroid glands
|5%-29% of people have these symptoms|
Bloating[ more ]
|Abnormal tongue morphology||0030809|
Enlarged colon lacking nerve cells
Swollen lymph nodes in the neck
|Cutaneous lichen amyloidosis||0032346|
|Disproportionate tall stature||0001519|
|Elevated circulating parathyroid
High blood calcium levels
Increased calcium in blood[ more ]
Elevated urine calcium levels
|Multiple mucosal neuromas||0031023|
|Neoplasm of the liver||
Liver tumor[ more ]
|Neoplasm of the lung||
|Neoplasm of the skeletal system||
|Paraganglioma of head and neck||0002864|
|Prominent corneal nerve fibers||0010726|
|Thick vermilion border||
Increased volume of lip
Thick lips[ more ]
|1%-4% of people have these symptoms|
Loosejointedness[ more ]
Wasting of muscles near the body
|Reduced subcutaneous adipose
Reduced fat tissue below the skin
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnoses include MTC and Hirschsprung disease (see these terms).
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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