The signs and symptoms of chorea-acanthocytosis usually begin in early to mid-adulthood. The movement problems of this condition worsen with age. Loss of cells (atrophy) in certain brain regions is the major cause of the neurological problems seen in people with chorea-acanthocytosis.
|Signs and Symptoms||Approximate number of patients (when available)|
|Abnormality of erythrocytes||90%|
|Neurological speech impairment||90%|
|Abnormality of coagulation||50%|
|Abnormality of the oral cavity||50%|
|Abnormality of urine homeostasis||50%|
|Attention deficit hyperactivity disorder||50%|
|Cerebral cortical atrophy||50%|
|Skeletal muscle atrophy||50%|
|Abnormality of the thyroid gland||7.5%|
|Acute hepatic failure||7.5%|
|Elevated hepatic transaminases||7.5%|
|Nausea and vomiting||7.5%|
|Recurrent respiratory infections||7.5%|
|Autosomal recessive inheritance||-|
|Elevated serum creatine phosphokinase||-|
|Limb muscle weakness||-|
|Self-mutilation of tongue and lips due to involuntary movements||-|
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