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Neuronal intranuclear inclusion disease (NIID) refers to a group of rare degenerative nerve diseases. Signs and symptoms of NIID are widespread, progressive, and usually begin in childhood. NIID causes worsening of many of the body's activities, including balance, movement, talking, eating, and cognition. Currently the cause of NIID is not known. Both sporadic and
Neuronal intranuclear inclusion disease (NIID) is a progressive disease (worsens over time) and long term
Parkinsonism - Abnormal movements, such as difficulty starting and controlling movement, stiffness of the trunk, arms, or legs, tremor, soft voice, and decrease in facial expressions.
Gastrointestinal dysfunction - For example intestinal pseudo-obstruction
Chorea - Involuntary muscle contractions and movements
Autonomic dysfunction - Some signs and symptoms include blood pressure problems, heart problems, and trouble with breathing and swallowing.
Over the course of 10 to 20 years NIID tends to become severely disabling and the effects become life threatening. While there is currently not a cure for NIID, research into the cause and treatment of neurodegenerative disorders like NIID is ongoing.