This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Sweating, increased[ more ]
|Intermittent painful muscle spasms||0011964|
|30%-79% of people have these symptoms|
Fear of open spaces
Difficulty in walking
|Exaggerated startle response||0002267|
|Paraspinal muscle hypertrophy||0012894|
|5%-29% of people have these symptoms|
|Percent of people who have these symptoms is not available through HPO|
|Asymmetric limb muscle stiffness||0007156|
Autoimmune disorder[ more ]
|Axial muscle stiffness||0006921|
|Proximal limb muscle stiffness||0007066|
Fast heart rate
Racing heart[ more ]
Blotchy loss of skin color
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
The following diseases are related to Stiff person syndrome. If you have a question about any of these diseases, you can contact GARD.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
I have been diagnosed with stiff person syndrome. In many ways it feels like an accurate assessment of my condition, better than numerous alternatives which were considered, but not across the board, in terms of what I have been reading. Are there any criteria which are necessary and sufficient, even overall convincing, to confirm the diagnosis? See answer
My husband and son have been diagnosed with stiff person syndrome. I am concerned about my other son and my grandson. Is there genetic testing for stiff person syndrome? See answer
A loved one has been diagnosed with stiff person syndrome. How can I learn more about treatments and clinical trials? See answer