Stiff person syndrome
(SPS) is a rare neurological disorder
with features of an autoimmune disease
. Symptoms may include muscle stiffness in the trunk and limbs, and heightened sensitivity to noise, touch, and emotional distress, which can set off muscle spasms. Affected people may also have abnormal postures, such as being hunched over. SPS affects twice as many women as men. It is frequently associated with other autoimmune diseases such as diabetes, thyroiditis
, and pernicious anemia
. The exact causes of SPS is not known. Treatment may involve high-dose diazepam
, anti-convulsants, or intravenous immunoglobulin (IVIG).
Last updated: 10/8/2014
Last updated: 10/8/2014
The National Institute of Neurological Disorders and Stroke (NINDS) has completed a clinical trial entitled 'Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS)'. The purpose of this study was to determine the effectiveness of intravenous immunoglobulin (IVIg) in the treatment of stiff person syndrome. Through this study, the researchers may have discovered information pertinent to your particular case. Further information about this study can be accessed through ClinicalTrials.gov. To read about this study, visit the hyperlink below. After you click on the study, review its information to determine if it provides you with useful information. http://www.clinicaltrials.gov/ct/show/NCT00001550?order=3
To locate information resulting from the completed study entitled 'Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS)' (study ID numbers 960062; 96-N-0062; NLM Identifier NCT00001550), you can either e-mail or call the National Library of Medicine (NLM) Customer Service. Include the title of the study, the study ID number, and the NLM Identifier, and a librarian at NLM can assist you in searching the medical literature for published results on the completed clinical trial.
National Library of Medicine Customer Service
The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. There are currently no studies recruiting new participants. To find trials in the future, click on the link below and use 'stiff person' as your search term. After you click on a study, review its 'eligibility' criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates. http://www.clinicaltrials.gov
You can also contact the Patient Recruitment and Public Liaison Office at the National Institutes of Health (NIH). We recommend calling the toll-free number listed below to speak with a specialist, who can help you determine if there are any other trials for which you may be eligible.
Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Web site: http://clinicalcenter.nih.gov/
If your loved on is interested in enrolling in a clinical trial, he or she can find helpful general information on clinical trials on the Web site of the Office of Rare Diseases (ORD), part of the National Institutes of Health. http://rarediseases.info.nih.gov/html/resources/ct-info-patient.html
A tutorial about clinical trials that can also help answer your questions can be found at the following link from the National Library of Medicine: http://www.nlm.nih.gov/medlineplus/tutorials/cancerclinicaltrials/htm/lesson.htm
Resources on many charitable or special-fare flights to research and treatment sites and low-cost hospitality accommodations for outpatients and family members, as well as ambulance services, are also listed on these ORD Web pages. http://rarediseases.info.nih.gov/Resources.aspx?PageID=8
Last updated: 10/8/2009
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please
GARD Information Specialist
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