Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

Title

Other Names:

AML with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22); AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11; AML with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22); AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11; Acute myelomonocytic leukemia See More

Categories:

Blood Diseases; Rare Cancers

This disease is grouped under:

Acute myeloid leukemia with recurrent genetic anomaly

Summary Summary

Acute myelomonocytic leukemia (AMML) is a cancer that typically develops in the bone marrow and blood of older individuals. AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly. Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia). The cause of AMML is currently unknown. Treatment typically consists of chemotherapy.^[1]

Last updated: 2/12/2013

Treatment Treatment

Acute myelomonocytic leukemia (AMML) is typically treated with chemotherapy, drugs injected into the bloodstream that target and destroy cancer cells. The amount and type of chemotherapy used to treat AMML depends on the age and health of the affected individual. The first step of chemotherapy for AMML is induction therapy, treatment with drugs that aim to destroy the cancer cells in the bone marrow and blood. Induction thearpy is followed by a rest phase to allow the affected individual to recover from the initial treatments. Then, the second step of chemotherapy is given, called consolidation therapy, which should destroy any cancer cells that may remain in the body.^[1] Stem cell transplant or participation in a clinical trial may also be used to treat AMML if chemotherapy treatments are unsuccessful.^[2]

Last updated: 2/12/2013

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Research Research

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Clinical Research Resources

ClinicalTrials.gov lists trials that are related to Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) . Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

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Learn More Learn More

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
PubMed is a searchable database of medical literature and lists journal articles that discuss Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) . Click on the link to view a sample search on this topic.

News & Events News & Events

News

NCATS Rare Diseases Are Not Rare! Challenge
October 9, 2018
The NIH Undiagnosed Diseases Network Expands
September 26, 2018

GARD Answers GARD Answers

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What is acute myelomonocytic leukemia and how is it best treated? Is there any research or new treatment currently in trials that is available to treat this disease? My father has just been diagnosed with this condition. See answer

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References References

American Cancer Society. Detailed Guide. Leukemia - Acute Myeloid (Myelogenous). January 2013; http://www.cancer.org/cancer/leukemia-acutemyeloidaml/detailedguide/index. Accessed 2/12/2013.
National Comprehensive Cancer Network. Acute Myeloid Leukemia. NCCN Clinical Practice Guidelines in Oncology. 2013; http://www.nccn.org/professionals/physician_gls/pdf/aml.pdf.

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