I have two sons with MCAD deficiency. I was recently told by the doctor that my sons will not be able to consume any alcohol when old enough to do so because it could lead to death. I would really like more information on this.
The United Mitochondrial Disease Foundation lists alcohol as a substance that people with mitochondrial disease should avoid, because alcohol has been known to hasten the progression of some mitochondrial disorders. In 2009, Lang reviewed several cases of MCAD deficiency diagnosed in adulthood. Many of these cases had alcohol consumption as a precipitating factor for an episode of metabolic crisis. Alcohol inhibits the breakdown (oxidation) of fatty acids in the liver, which can lead to the toxic accumulation of fatty acids within cells. In the cases reviewed by Lang, the consumption of alcohol also led to vomiting, which may have caused symptoms due to a period of fasting.
To learn more about the dietary guidelines for MCAD deficiency, we recommend that you contact the following organizations:
United Mitochondrial Disease Foundation 8085 Saltsburg Road, Suite 201 Pittsburg PA 15239 Toll-free: 1-888-317-UMDF Telephone: 412-793-8077 Fax: 412-793-6477 E-mail: email@example.com Web site: http://www.umdf.org