Alpers syndrome is a progressive neurologic disorder that begins during childhood and is complicated in many instances by serious liver disease. Symptoms include increased muscle tone with exaggerated reflexes (spasticity), seizures, and loss of cognitive ability (dementia).  Most often Alpers syndrome is caused by mutations in the POLG gene. 
Last updated: 1/24/2011
How might Alpers syndrome be treated?
Treatment for Alpers syndrome is limited to managment of symptoms and supportive care. There is currently no cure. 
A multi-disciplinary medical team of a gastroenterologist, neurologist, occupational, physical and/or speech therapist can assist with management of symptoms to maintain function as long as possible, insure comfort and promote the best possible quality-of-life. 
Last updated: 5/26/2011
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