The following information may help to address your question:
Amelogenesis imperfecta can have different patterns of inheritance, depending on the
Amelogenesis imperfecta may also be inherited in an autosomal recessive pattern; this form of the disorder can result from mutations in the ENAM or MMP20 gene. Autosomal recessive inheritance means two copies of the gene in each cell are altered.
About 5 percent of amelogenesis imperfecta cases are caused by mutations in the AMELX gene and are inherited in an
In some cases, the genetic cause of amelogenesis imperfecta can not been identified. Researchers are working to find mutations in other genes that are responsible for this disorder.
Click on each gene name to learn more about the role it plays in the development of tooth enamel.