AL amyloidosis is frequently associated with chromosome anomalies. The anomalies that have been described in association with amyloidosis are numberous and varied. As a result, no single chromosome anomaly is characteristic for this condition.
One study did find an extra chromosome X (trisomy X) in 13% of women and 54% of men with systemic amyloidosis in their study population. We were not able to find a study which investigated the prevalence of chromosome 16 anomalies. One of the more common chromosome anomalies associated with systemic amyloidosis is a loss of a copy of chromosome 18 (i.e., chromosome 18 monosomy). In one study this anomaly was identifed in 72% of participants.
Last updated: 9/24/2013
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please