The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
| Signs and Symptoms | Approximate number of patients (when available) |
| Fever | Very frequent (present in 80%-99% of cases) |
| Headache | Very frequent (present in 80%-99% of cases) |
| Hemolytic anemia | Very frequent (present in 80%-99% of cases) |
| Arthralgia | Frequent (present in 30%-79% of cases) |
| Cough | Frequent (present in 30%-79% of cases) |
| Fatigue | Frequent (present in 30%-79% of cases) |
| Hepatomegaly | Frequent (present in 30%-79% of cases) |
| Hyperhidrosis | Frequent (present in 30%-79% of cases) |
| Jaundice | Frequent (present in 30%-79% of cases) |
| Leukopenia | Frequent (present in 30%-79% of cases) |
| Myalgia | Frequent (present in 30%-79% of cases) |
| Splenomegaly | Frequent (present in 30%-79% of cases) |
| Thrombocytopenia | Frequent (present in 30%-79% of cases) |
| Anorexia | Occasional (present in 5%-29% of cases) |
| Clinodactyly of the 5th toe | Occasional (present in 5%-29% of cases) |
| Coma | Occasional (present in 5%-29% of cases) |
| Confusion | Occasional (present in 5%-29% of cases) |
| Congestive heart failure | Occasional (present in 5%-29% of cases) |
| Depression | Occasional (present in 5%-29% of cases) |
| Hepatic failure | Occasional (present in 5%-29% of cases) |
| Hypercoagulability | Occasional (present in 5%-29% of cases) |
| Limitation of joint mobility | Occasional (present in 5%-29% of cases) |
| Myocardial infarction | Occasional (present in 5%-29% of cases) |
| Nausea and vomiting | Occasional (present in 5%-29% of cases) |
| Photophobia | Occasional (present in 5%-29% of cases) |
| Recurrent pharyngitis | Occasional (present in 5%-29% of cases) |
| Renal insufficiency | Occasional (present in 5%-29% of cases) |
| Respiratory insufficiency | Occasional (present in 5%-29% of cases) |
| Venous thrombosis | Occasional (present in 5%-29% of cases) |
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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