Bilateral frontoparietal polymicrogyria (BFPP) is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). BFPP specifically affects the frontal and parietal lobes on both sides of the brain (bilateral). Signs and symptoms typically include moderate to severe intellectual disability, developmental delay, seizures, cerebellar ataxia, strabismus, and dysconjugate gaze (eyes that are not aligned). Some cases are caused by mutations in the GPR56gene and are inherited in an autosomal recessive manner. Treatment is based on the signs and symptoms present in each person.
Last updated: 6/8/2015
What are the signs and symptoms of bilateral frontoparietal polymicrogyria?
The signs and symptoms of bilateral frontoparietal polymicrogyria vary but may include:
Finger dysmetria (difficulty controlling speed, distance and/or power of movements)
Last updated: 6/7/2015
What are the signs and symptoms of bilateral perisylvian polymicrogyria?
Signs and symptoms of bilateral perisylvian polymicrogyria (BPP) usually are apparent at birth or become apparent during infancy or childhood. The signs and symptoms, and severity, vary from person to person but may include:
Partial paralysis of muscles on both sides of the face, tongue, jaw, and throat
Sudden, involuntary spasms of facial muscles
Difficulty with sucking, chewing, and/or swallowing (dysphagia)
Kilinc O, Ekinci G, Demirkol E & Agan K. Bilateral agenesis of arcuate fasciculus demonstrated by fiber tractography in congenital bilateral perisylvian syndrome. Brain Dev. March 2015; 37(3):352-355. https://www.ncbi.nlm.nih.gov/pubmed/24852949.