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The prognosis for Cockayne syndrome varies by the disease type. There are three types of Cockayne syndrome:
Cockayne Syndrome Type 1 (type A) is marked by normal development until a child is 1 or 2 years old, at which point growth slows and developmental delays are noticed. Life expectancy for type 1 is approximately 10 to 20 years.Cockayne syndrome type 2 (type B), also known as cerebro-oculo-facio-skeletal (COFS) and Pena-Shokeir syndrome type II, has severe symptoms present at birth and normal brain development stops after birth. Average lifespan for children with type 2 is up to 7 years of age.