The main features of cramp-fasciculation syndrome, muscle cramps and twitches (fasciculations), are common symptoms that often occur in otherwise healthy people. In these cases the symptoms may be triggered by muscle overuse, dehydration, lack of nutrients in the diet, lack of blood flow to the muscles, side effect of medications, sleep apnea, or stress. These symptoms come and go and rarely last for more than a few days.
Cramp-fasciculation syndrome by definition is a non-progressing, benign disease. If a person with cramp fasciculation syndrome experiences a worsening of symptoms, a careful evaluation to rule out other diagnoses is recommended.
Last updated: 9/19/2016
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Singh V, Gibson J, McLean B, Boggild M, Silver N, and White R. Fasciculations and cramps: how benign? Report of four cases progressing to ALS. J Neurol. April 2011; 258(4):573-8. http://www.ncbi.nlm.nih.gov/pubmed/20967550.