|Signs and Symptoms||Approximate number of patients (when available)|
|Abnormality of the nail||90%|
|Abnormal blistering of the skin||7.5%|
|Autosomal dominant inheritance||-|
|Bipolar affective disorder||-|
|Enlargement of parotid gland||-|
|Intellectual disability, mild||-|
|Subungual hyperkeratotic fragments||-|
The affected skin may smell unpleasant, which may be due to bacteria growing in the rash. If bacterial overgrowth is suspected or there is a lot of crusting, it can be helpful to apply antiseptics or soak in astringents.
Topical medications may include topical retinoids (i.e., adapalene, tazarotene gel, or tretinoin). Topical retinoids may reduce hyperkeratosis within 3 months. However, irritation is a side effect. Other medications may include acitretin, isotretinoin, cyclosporine, or oral retinoids (eg, acitretin, isotretinoin). Oral retinoids have been the most effective medical treatment for Darier disease, leading to reduction of symptoms in 90% of affected people. However, prolonged use is limited due to adverse effects.
Other treatments may include oral antibiotics to clear bacterial infection, oral acyclovir to treat or suppress herpes simplex virus infection; dermabrasion; electrosurgery; and Mohs micrographic surgery for localized areas.
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I would be very grateful for some information about treatment of Darier disease during pregnancy, particularly in cases where symptoms are exacerbated. See answer
My sister has Darier disease. Is this condition genetic? Are my children at risk to develop this condition? If so, what can be done to help prevent a flare-up? See answer
I have had the diagnosis of Darier disease for many years. My skin has recently been getting worse. I'm looking for more information about treatment, research and how to find a dermatologist in my area who has experience with this condition. See answer