The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
|Signs and Symptoms||Approximate number of patients (when available)|
|Deeply set eye||50%|
|Abnormal form of the vertebral bodies||7.5%|
|Abnormal localization of kidney||7.5%|
|Abnormality of the pupil||7.5%|
|Aplasia/Hypoplasia of the iris||7.5%|
|Aplasia/Hypoplasia of the radius||7.5%|
|Aplasia/Hypoplasia of the thumb||7.5%|
|External ear malformation||7.5%|
|Wide nasal bridge||7.5%|
More detailed information about the treatment of Duane syndrome is available on Medscape Reference's Web site and can be viewed here. You may need to register to view this information, but registration is free.
Nonprofit support and advocacy groups bring together patients, families, medical professionals, and researchers. These groups often raise awareness, provide support, and develop patient-centered information. Many are the driving force behind research for better treatments and possible cures. They can direct people to research, resources, and services. Many groups also have experts who serve as medical advisors. Visit their website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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I have isolated Duane retraction syndrome. My left has retracted inward towards the nose and it appears smaller than the right. The last few years it really bothers me. I was wondering if there is anything I could do about it. I usually close my big eye a little bit so that they can appear even, but recently I noticed my left eye closing even more. This problem only increases with my left eye getting smaller over the years and it makes a really bad image of my face. If there is anything you can tell me that helps my condition I would be grateful. See answer
Duane syndrome affects my left eye. I have constant ringing in my left ear and neck pain when I look over my left shoulder. Are these issues related to Duane syndrome? My doctors did not know the answer. See answer
My daughter has Duane retraction syndrome. She is also left-handed and has very small ears and ear lobes. No one else on my side of the family, or her father's, have these signs. When her father was younger he experimented with LSD. I don't know how many times he took the drug. I remember hearing years ago that people who have taken LSD might have offspring with missing chromosomes. Has this been verified as being one cause of the major missing chromosome for DRS? See answer
I was born with Duane syndrome. Now I am close to the stage of deciding to have children. What are the chances of my children being born with Duane syndrome? See answer
Can in vitro fertilization cause Duane syndrome? See answer
I have Duane syndrome. These is no known family history. What the probability of passing this condition on to any future offspring? See answer
If a first child is affected by Duane syndrome, what is the likelihood that subsequent children will also be affected? Should genetic counseling be done prior to attempting a second pregnancy? See answer