The best treatment options for Evans syndrome depend on many factors, including the severity of the condition; the signs and symptoms present; and each person's response to certain therapies. For example, people who need to be hospitalized due to severe anemia or thrombocytopenia are often treated with blood transfusions followed by therapy with corticosteroids or intravenous (IV) immune globulin. Other treatment options include immunosuppressive drugs. Most affected individuals respond to these treatments; however, relapse is frequent.
In people who do not respond to standard treatments, therapy with rituximab or splenectomy may be considered. Some people with Evans syndrome respond well to rituximab treatment and experience an extended period of remission, while others have little to no response. People undergoing splenectomy may show immediate improvement; however, relapses are common and, in most cases, occur within 1-2 months after the procedure.
Who can I contact to learn more about the management of Evans syndrome?
The Evans Syndrome Research and Support Group was founded with the purpose of locating families affected by Evans syndrome, gathering information about the disease, and offering support. Over the years they have identified many physicians who are knowledgeable about the management of Evans syndrome. You can access a listing of these physicians at the following link or by contacting the organization directly. http://www.evanssyndrome.org/esphysicians.htm