Is it safe for someone with factor V Leiden to use oral contraceptives?
In general, it is widely accepted that in women with factor V Leiden, hormones such as oral contraceptives and hormone replacement therapy increases the risk of blood clots. We strongly recommend you speak with your doctor about the risks and benefits of taking any sort of contraceptive or hormone replacement therapy.
According to the practice guidelines set forth by the American College of Obstetrics and Gynecology, women with familial thrombophilic syndromes, including factor V Leiden mutation, have an increased risk of venous thromboembolism during oral contraceptive use and also developing venous thromboembolism earlier during use than lower risk users. An initial study concluded that women with a factor V Leiden mutation had an eight-fold increased risk of venous thromboembolism than did women without the mutation. The risk was more than 30 times higher in carriers who used oral contraceptives than in non-oral contraceptive users who were not carriers of the mutation. However, most of these women will never experience venous thromboembolism, even if they used combination oral contraceptives.
The American Society of Hematology has a tool on their Web site to help patients find a hematologist in their area. You can search by location and specialty, such as thrombosis and blood clotting. You can click on the link below to view this search tool. http://store.hematology.org/Default.aspx?tabid=231
Last updated: 9/8/2011
How can I find a genetics professional in my area?
ACOG Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. No. 73: Use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006; 107(6):1453-72. http://www.ncbi.nlm.nih.gov/pubmed/16738183. Accessed 9/8/2011.