Wondering if there is a connection between factor V Leiden and breast cancer? I have read that many people with breast cancer have factor V Leiden, but wondering which came first? I have asked many people and no one seems to have the answer.
No. Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of people with European ancestry carry one copy of the factor V Leiden mutation in each cell. Factor V Leiden and breast cancer are not known to be causally related; however, due to the high prevalence of mutations, it is quite possible for women with breast cancer to also have a mutation in factor V Leiden. In addition, testing for factor V Leiden (and other common genetic risk factors for thrombophilic events) may be ordered for breast cancer patients to assess risks for blood clots and stroke. For example, a number of studies have been done assessing the rate of tamoxifen-associated thrombophilic events in breast cancer patients with factor V Leiden mutations.
Last updated: 8/22/2013
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