This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Pain in stomach
Stomach pain[ more ]
Muscle pain[ more ]
|Nausea and vomiting||0002017|
|30%-79% of people have these symptoms|
Oral white patch
Inflammation of tissues lining lungs and chest
High urine protein levels
Protein in urine[ more ]
|5%-29% of people have these symptoms|
|Acute hepatic failure||
Acute liver failure
Abnormal heart rate
Heart rhythm disorders
Irregular heart beat
Irregular heartbeat[ more ]
Accumulation of fluid in the abdomen
Death of digestive organ tissue due to poor blood supply
Intestinal blockage[ more ]
Swollen lymph nodes
Too much calcium deposited in kidneys
Inflammation of testicles
Degenerative joint disease
Fluid accumulation in lower limbs
Lower leg swelling[ more ]
Swelling or irritation of membrane around heart
Increased spleen size
Inflammation of blood vessel
|1%-4% of people have these symptoms|
Infrequent bowel movements
|Episodic abdominal pain||0002574|
Increased body temperature, episodic
Intermittent fever[ more ]
|Stage 5 chronic
|Percent of people who have these symptoms is not available through HPO|
Symptoms begin in childhood
Onset in first year of life
Onset in infancy[ more ]
Signs and symptoms begin before 15 years of age
Elevated white blood count
High white blood count
Increased blood leukocyte number[ more ]
Increased blood neutrophil counts
Fluid around lungs
|Young adult onset||0011462|
As many as 1 in 5 people of Sephardic Jewish, Armenian, Arab and Turkish heritage is a carrier of FMF.
In rare cases, FMF appears to be inherited in an
In some cases, FMF may appear to be autosomal dominant when it is actually autosomal recessive. This phenomenon is called pseudodominance.
Depending on disease severity or the presence of specific
There may be other treatments for this condition that have been approved in Europe and other parts of the world.
Learn more orphan products.
If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.
If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.
You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnoses include hyperimmunoglobulinemia D and periodic fever syndrome (HIDS), TNF receptor-associated periodic syndrome and periodic fever (TRAPS), Marshall's syndrome with periodic fever, transthyretin-related amyloidosis and Behçet's disease (see these terms).
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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