The following information may help to address your question:
So far studies investigating the use of bisphosphonate therapies for treatment of fibrous dysplasia have been small and uncontrolled. Further information regarding the benefits and complications associated with bisphosphonate therapy for treatment of fibrous dysplasia is likely on the horizon. The National Institute of Dental and Craniofacial Research at the National Institutes of Health completed a three year, phase 2, clinical trial of Fosamax (Alendronate) for treatment of fibrous dysplasia. The clinical trial was entitled 'Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome.' Click here to view the study information. In our search, we were unable to find published results from the trial. You can contact the National Library of Medicine (NLM) Customer Service for further assistance in searching the medical literature for published results.
National Library of Medicine Customer Service
In addition, there is an ongoing clinical trial in Europe, entitled Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone (PROFIDYS), that is investigating the efficacy of oral bisphosphonate to decrease bone pain and improve radiological appearance of fibrous dysplasia. Click on the title above to learn more.