What are the signs and symptoms of glutaric acidemia type 1?
The specific symptoms and severity in people with glutaric acidemia type 1 (GA1) can vary widely. Some people are mildly affected, while others have severe problems. Signs and symptoms usually first occur in infancy or early childhood, but sometimes symptoms begin in adolescence or adulthood.
Some infants with GA1 have a large head circumference (macrocephaly). Other features that may occur in affected people include difficulty moving; experiencing spasms, jerking, rigidity, or decreased muscle tone; and intellectual disability. Stress on the body (such as infection and fever) can cause worsening of symptoms.
Last updated: 4/29/2015
Can glutaric acidemia type 1 cause stomach issues, such as high acidity?
People with glutaric acidemia type 1 are prone to develop pancreatitis.
Pancreatitis is inflammation of the pancreas. The pancreas is a large
gland behind the stomach and close to the first part of the small
intestine. It secretes digestive juices into the small intestine through
a tube called the pancreatic duct. The pancreas also releases the
hormones insulin and glucagon into the bloodstream. Pancreatitis can be
acute (sudden severe onset) or chronic. Either form is serious and can
lead to complications. Common symptoms are severe pain in the upper
abdomen, nausea, and vomiting. For more information on pancreatitis,
visit MedlinePlus.gov at the following link: http://www.nlm.nih.gov/medlineplus/pancreatitis.html
Last updated: 3/5/2014
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