Hemolytic uremic syndrome (HUS) is a disorder that usually occurs when an E. coli bacterial infection in the digestive system produces toxic substances that destroy red blood cells. Symptoms include vomiting and diarrhea, fever, lethargy, and weakness. In severe cases it can lead to kidney failure or death. While this condition is most common in children, it often has a more complicated presentation in adults. Treatment may include
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|Percent of people who have these symptoms is not available through HPO|
|Acute kidney injury||0001919|
Absent urine output
Abnormality of cognition
Mental impairment[ more ]
|Decreased serum complement C3||0005421|
|Decreased serum complement factor B||0005416|
|Decreased serum complement factor H||0005369|
|Decreased serum complement factor I||0005356|
|Elevated serum creatinine||
High blood creatinine level
Increased serum creatinine[ more ]
|Increased blood urea nitrogen||0003138|
Low platelet count
With proper management, most children who develop hemolytic uremic
However, children with hemolytic uremic syndrome may have serious and sometimes life-threatening complications, including:
Some children may sustain significant kidney damage that slowly develops into chronic kidney disease (CKD). Children who develop CKD must receive treatment to replace the work the kidneys do, either through
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Got a Great Research Idea? ‘All of Us’ Wants to Hear It!
January 18, 2018
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
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I was diagnosed with hemolytic uremic syndrome as an infant. I developed kidney and heart failure and received several blood transfusions. At the age of 15 I was put on blood pressure medication. Is kidney disease/dialysis part of the long-term outlook for people who were affected by this condition as a child? See answer