People with HUV syndrome have hives (urticaria) for at least six months and low levels of proteins (complement) in the blood. Complement levels can be determined through a blood test. Click here to visit the American Association for Clinical Chemistry's Web site Lab Tests Online to learn more about this test.
In addition to these major criteria, people with HUV syndrome must also have at least two of the following minor criteria:
Inflammation in the small veins of the dermis (diagnosed by biopsy)
Joint pain or arthritis
Inflammation in the eye (uvea or episclera)
Recurrent abdominal pain
The presence of anti-C1q antibodies (this test is not widely available)
Some people have urticarial vasculitis and low complement levels (hypocomplementemia), but do not meet diagnostic criteria for HUV syndrome. These individuals may be diagnosed as having HUV (where symptoms are limited to the skin), versus HUV syndrome.
Differential diagnoses for HUV syndrome include, Schnitzler's syndrome, Cogan's syndrome, and Muckle-Wells syndrome.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Workshop on Systemic Vasculitis: Future Research Directions Monday, September 15, 1997
Location: NIH Campus, Bethesda, MD
Contact: Dr. Howard Dickler(301) 496-7104
Co-funding Institute(s): National Institute of Allergy and Infectious Diseases
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
What tests are used for hypocomplementemic urticarial vasculitis? I noticed while reading your site that hypocomplementemic urticarial vasculitis seemed to fit my symptoms. Are there tests specifically for this condition as opposed to another type of urticaria angioedema? See answer