This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|100% of people have these symptoms|
Recurrent low potassium
|Periodic hypokalemic paresis||0008153|
|80%-99% of people have these symptoms|
|Episodic flaccid weakness||0003752|
|Increased intramyocellular lipid droplets||0012240|
|Mildly elevated creatine phosphokinase||0008180|
|30%-79% of people have these symptoms|
|Exercise-induced muscle fatigue||0009020|
|5%-29% of people have these symptoms|
|Late-onset proximal muscle weakness||0003694|
Muscle tissue disease
|1%-4% of people have these symptoms|
|Fatigable weakness of respiratory muscles||0030196|
|Percent of people who have these symptoms is not available through HPO|
Low blood potassium levels
|Periodic hyperkalemic paralysis||0007215|
Various types of tests including blood tests, urine tests, and/or electromyograms may be used to differentiate between primary HOKPP and other possible causes of symptoms.
Of all individuals who meet diagnostic criteria and have
The resources below provide information about treatment options for this condition. If you have questions about which treatment is right for you, talk to your healthcare professional.
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Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
My 26 year old son has been recently diagnosed with hypokalemic periodic paralysis. No other family members including myself, his mother, or his sister have shown any symptoms of this. He had not shown any symptoms until the past 6 months. Is it likely his sister will also have this disorder? Is it likely my brother's children will be affected? There is no record of any parents or other family members being affected. See answer
I have hypokalemic periodic paralysis and plan on having children soon. Could my condition worsen during pregnancy and/or childbirth? Does this condition affect the development of a fetus? How rare is this condition in African Americans? See answer