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The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
| Signs and Symptoms | Approximate number of patients (when available) |
| Alopecia | Frequent (present in 30%-79% of cases) |
| Anorexia | Frequent (present in 30%-79% of cases) |
| Cutaneous photosensitivity | Frequent (present in 30%-79% of cases) |
| Erythema | Frequent (present in 30%-79% of cases) |
| Fatigue | Frequent (present in 30%-79% of cases) |
| Leukopenia | Frequent (present in 30%-79% of cases) |
| Low-grade fever | Frequent (present in 30%-79% of cases) |
| Night sweats | Frequent (present in 30%-79% of cases) |
| Oral ulcer | Frequent (present in 30%-79% of cases) |
| Palpebral edema | Frequent (present in 30%-79% of cases) |
| Pruritus | Frequent (present in 30%-79% of cases) |
| Skin nodule | Frequent (present in 30%-79% of cases) |
| Skin rash | Frequent (present in 30%-79% of cases) |
| Vasculitis in the skin | Frequent (present in 30%-79% of cases) |
| Weight loss | Frequent (present in 30%-79% of cases) |
| Abnormal blistering of the skin | Occasional (present in 5%-29% of cases) |
| Abnormality of the gastrointestinal tract | Occasional (present in 5%-29% of cases) |
| Abnormality of the neck | Occasional (present in 5%-29% of cases) |
| Occasional (present in 5%-29% of cases) |
|
| Antinuclear |
Occasional (present in 5%-29% of cases) |
| Arthralgia | Occasional (present in 5%-29% of cases) |
| Elevated C-reactive |
Occasional (present in 5%-29% of cases) |
| Elevated |
Occasional (present in 5%-29% of cases) |
| Elevated hepatic transaminases | Occasional (present in 5%-29% of cases) |
| Enlargement of parotid gland | Occasional (present in 5%-29% of cases) |
| Interstitial pulmonary abnormality | Occasional (present in 5%-29% of cases) |
| Lymphocytosis | Occasional (present in 5%-29% of cases) |
| Macule | Occasional (present in 5%-29% of cases) |
| Occasional (present in 5%-29% of cases) |
|
| Myalgia | Occasional (present in 5%-29% of cases) |
| Neutropenia | Occasional (present in 5%-29% of cases) |
| Papule | Occasional (present in 5%-29% of cases) |
| Skin erosion | Occasional (present in 5%-29% of cases) |
| Skin plaque | Occasional (present in 5%-29% of cases) |
| Splenomegaly | Occasional (present in 5%-29% of cases) |
| Occasional (present in 5%-29% of cases) |
|
| Very rare (present in 1%-4% of cases) |
|
| Generalized lymphadenopathy | Very rare (present in 1%-4% of cases) |
| Hepatomegaly | Very rare (present in 1%-4% of cases) |
| Myocarditis | Very rare (present in 1%-4% of cases) |
| Pleural effusion | Very rare (present in 1%-4% of cases) |
| Pustule | Very rare (present in 1%-4% of cases) |
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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Can this affect young men also? My son who is 34 always has swollen lymph nodes/glands and has mixed connective tissue disease (MCTD). He feels very poor most of the time but can't seem to get a diagnosis. See answer
I was diagnosed with Kikuchi's disease a number of years ago. I had a lump on the side of my neck that kept on getting bigger. An ear nose and throat specialist did surgery to remove it. Biopsy confirmed that it was Kikuchi's disease. The ear nose and throat specialist informed me that I would have these lumps throughout my body for the rest of my life. Is this true? According to what I have been reading online it is supposed to go away after just a few months? I have a new lump on the other side of my neck now that has been getting bigger and it hurts. I had an MRI done and they said that it is only 1 cm wide on the inside but on the outside it was 5cm by 6cm. Do you think that I should have this removed? See answer
I am suffering from Kikuchi disease. What kind of treatment should I undergo and is taking painkillers the right treatment? See answer
