Muscle weakness may vary in severity and can lead to:
Vision issues may additionally occur including:
Other symptoms may include blood pressure changes, dizziness upon rising, and dry mouth.
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|EMG: decremental response of compound muscle action potential to repetitive nerve stimulation||0003403|
|EMG: repetitive nerve stimulation abnormality||0030000|
|Progressive proximal muscle weakness||0009073|
|Reduced tendon reflexes||0001315|
Dry mouth syndrome
Reduced salivation[ more ]
|30%-79% of people have these symptoms|
Difficulty getting a full erection
Difficulty getting an erection
Erectile dysfunction[ more ]
|5%-29% of people have these symptoms|
Decreased ability to sweat
Sweating, decreased[ more ]
|Orthostatic hypotension due to autonomic dysfunction||0004926|
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Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
In 60% of LEMS patients, a different diagnosis was initially made such as myasthenia gravis (MG), inclusion body myositis, Guillain-Barré syndrome (GBS), amyotrophic lateral sclerosis (ALS) (see these terms), lumbar canal stenosis, early-phase Parkinson's disease and lower body parkinsonism.
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
My husband had Lambert Eaton myasthenic syndrome. Are our two children at risk to develop this condition? See answer
My husband has Lambert Eaton myasthenic syndrome. We read somewhere that this condition may be caused by an anesthetic. I'm now unable to locate that information. Is that true? If so, what anesthetic? See answer