I have Ledderhose disease and Dupuytren's contracture. I also have a family history of these conditions. My condition has worsened despite multiple surgeries. Is there a satisfactory treatment for Ledderhose?
There is little evidence regarding the effectiveness of specific treatment approaches for Ledderhose disease. Initial treatment approach may invovle regular (monthly or less often) glucocorticoid injection and soft shoe inserts with cutouts for the nodules. Surgery, such as selective fasciectomy or dermofasciectomy, has been used as treatment of people who do not respond to initial therapy. Recurrence following surgery is common. Collagenase injection is an additional therapy which has been used with variable sucess.
Our search identified one case report describing the use of "upper lateral arm flaps" on the feet of two brother's who had multiple recurrences following other procedures. The reference for this article is provided below.
Kan HJ, Hovius SE. Long-term follow-up of flaps for extensive Dupuytren's and Ledderhose disease in one family. J Plast Reconstr Aesthet Surg. 2012 Dec;65(12):1741-5; http://www.ncbi.nlm.nih.gov/pubmed/22917697. Accessed 6/28/2013.
Watt AJ, Curtin CM, Hentz VR. Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up. J Hand Surg Am. 2010 Apr;35(4):534-9, 539.e1; http://www.ncbi.nlm.nih.gov/pubmed/20353858. Accessed 6/28/2013.