Legg-Calve-Perthes disease (LCPD) is usually not caused by genetic factors (thus is usually not inherited), but a few familial cases with autosomal dominant inheritance have been reported. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible. In some cases, it appears that genetic and environmental factors interact to increase a person's chance to develop LCPD.
Last updated: 7/28/2016
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