Legg-Calve-Perthes disease (LCPD) is usually not caused by genetic factors (thus is usually not inherited), but there are some cases where LCPD affects more than one family member. In a small percentage of these familial cases, changes or mutations in the COL2A1gene have been found to cause LCPD. When mutations in COL2A1 gene are the cause of LCPD, the disease is inherited in an autosomal dominant manner. In some cases, it appears that genetic and environmental factors interact to increase a person's chance to develop LCPD.
Last updated: 9/13/2016
We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please