I was diagnosed with McCune Albright when I was 16. I was wondering the risks of pregnancy with McCune Albright? I am 20 now and already had 1 miscarriage. I want to know if this is possibly from my syndrome?
Although a lot is known about McCune Albright syndrome (MAS) in children, issues arising specifically during adulthood are less well understood. Precocious puberty can lead to abnormal gonad (ovary or testes) function and problems with fertility in adults. Women with MAS are susceptible to developing large ovarian cysts and irregular vaginal bleeding. This can interfere with normal ovulation. Some affected women experience anovulation (when an egg is not released from the ovaries). In most cases, adults with MAS have been able to have children, even if it may take longer than normal to conceive. Endometrial function may be also affected due to elevated progesterone levels throughout the cycle, which may make implantation of an embryo difficult. In some cases, removal of the affected ovary (ovariectomy) may improve endocrine function and the function of the remaining ovary, thus improving fertility.
Reports have shown that during pregnancy in women with MAS, the rate of bone turnover (when the body removes old bone that should then be replaced) is increased compared with unaffected pregnant women, suggesting that pregnancy could induce changes of bone metabolism. Some researchers have suggested there may be an increased risk of tumor development during pregnancy (i.e. an increased risk of fibrous dysplasia developing into osteosarcoma). However, further studies are needed to clarify the relationship between pregnancy and tumor development in women with MAS.
Last updated: 1/3/2014
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