This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Autoimmune disorder[ more ]
Tiredness[ more ]
Acid reflux disease
Heartburn[ more ]
|30%-79% of people have these symptoms|
Dry mouth syndrome
Reduced salivation[ more ]
|5%-29% of people have these symptoms|
|Interstitial pulmonary abnormality||0006530|
Stiff joints[ more ]
Decreased blood leukocyte number
|Prolonged bleeding time||0003010|
Increased spleen size
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
Workshop on Heritable Disorders of Connective Tissue Sunday, June 4, 1995 -
Tuesday, June 6, 1995
Location: Bethesda, MD
Description: As a result of this workshop, the participants recognized the joint efforts of clinicians, scientists, and patients in maintaining tissue and patient registries.
Co-funding Institute(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
What can my son expect with this disease? He is 27 years old. Is this going to be disabling? See answer
What is the treatment or remedy of mixed connective tissue disorder? See answer
What causes mixed connective tissue disease? Is it genetic? Is it due to environmental exposures? See answer