The following information may help to address your question:
What is myasthenia gravis?
(MG) is a chronic autoimmune neuromuscular
disease characterized by weakness of the skeletal muscles of the body. Common symptoms include weakness of the muscles that control the eye and eyelid; facial expressions; chewing; talking; and swallowing. Weakness tends to increase during periods of activity and improves after periods of rest. Myasthenia gravis results from a defect in the transmission of nerve impulses to muscles, due to the presence of antibodies
against the acetylcholine
However, the exact cause is unknown. Some cases have been linked to tumors in the thymus gland
Researchers believe that variations in certain genes
may increase a person's risk to develop this condition, but it is likely that other factors also play a role.
There is no cure for myasthenia gravis yet, but treatment can significantly improve muscle weakness. Some case of myasthenia gravis may go into remission temporarily, and muscle weakness may disappear so that medications can be discontinued.
Last updated: 10/28/2016
What are the signs and symptoms of myasthenia gravis?
Myasthenia gravis can affect any voluntary muscle. Voluntary muscles are the muscles that we directly control to make our body do things like walk, run, write, throw, lift, smile, and chew. In myasthenia gravis the most commonly affected muscles are the muscles that control eye and eyelid movement, facial expression, and swallowing. The degree of muscle weakness varies from person to person. People with more severe disease may have many muscles affected, including the muscles that control breathing. People with mild disease may have only one muscle group involved, such as the eye muscles.
In general, signs and symptoms of myasthenia gravis may include a drooping of one or both eyelids (ptosis); blurred or double vision (diplopia); unstable or waddling gait; weakness in the arms, hands, fingers, legs, and neck; a change in facial expression; difficulty in swallowing and shortness of breath; and impaired speech (dysarthria).
People can develop myasthenia gravis at any age. For unknown reasons, it is most commonly diagnosed in women younger than age 40 and men older than age 60. It is uncommon in children, but some infants born to women with myasthenia gravis have signs and symptoms of the condition for the first few days or weeks of life. This temporary occurrence of symptoms is called transient neonatal myasthenia gravis
Last updated: 10/29/2016
What causes myasthenia gravis?
The exact cause of myasthenia gravis is unknown, but it is likely that many factors contribute to the risk of developing this disorder.
Myasthenia gravis is a type of autoimmune disorder
. Autoimmune disorders occur when the immune system mistakenly attacks healthy tissue.
In myasthenia gravis, the body produces antibodies that block the muscle cells that receive messages (neurotransmitters) from the nerve cells.
Normally when impulses travel down the nerve, the nerve endings release a neurotransmitter substance called acetylcholine. Acetylcholine travels from the neuromuscular junction - the place where nerve cells connect with the muscles they control - and binds to acetylcholine receptors which are activated and generate a muscle contraction. In myasthenia gravis, antibodies block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction,which prevents the muscle contraction from occurring. These antibodies are produced by the body's own immune system.
In some cases, myasthenia gravis it is linked to tumors or other abnormalities of the thymus (a gland the plays an important role in the immune system).
Researchers also believe that variations in particular unidentified genes may increase the risk to develop myasthenia gravis. Ultimately, many factors likely contribute to the risk of developing this complex disorder.
Last updated: 10/29/2016
How can I learn more about how myasthenia gravis affects my body?
offers a comprehensive list of resources for myasthenia gravis. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions. The Myasthenia Gravis Foundation of America
also has information related to this topic.
You can also use the navigation menu on the left hand side of this page to view many additional resources on myasthenia gravis.
Last updated: 2/9/2016
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