The term "nocturnal" refers to the belief that hemolysis is triggered by acidosis during sleep. However, this observation was later disproved. In individuals with paroxysmal nocturnal hemoglobinuria, hemolysis has been shown to occur throughout the day, but the urine concentrated overnight produces the dramatic change in color. It is most noticeable in the morning, upon passing urine that has accumulated in the bladder during the night.
Last updated: 1/15/2011
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