The following information may help to address your question:
Diagnosis can be confirmed by blood tests. Blood tests show significantly lower-than-normal levels of T
Since there are other conditions that can result in lower-than-normal numbers of the different types of
Immunoglobulin levels are usually very low in SCID. Most commonly (but not always), all immunoglobulin classes are depressed (IgG, IgA, IgM and IgE).
The diagnosis of SCID can also be made before the baby is born if there has been another infant in the family with the disorder and if the gene defect has been identified. If genetic analysis had been completed on the infant in the family with SCID, a diagnosis can be determined during subsequent pregnancies. This can be done by molecular testing of cells from a chorionic villous sampling (
Early diagnosis, before the infant has had a chance to develop any infections, is very valuable since bone marrow transplants given in the first three months of life have a 94% success rate. In fact,
For further details on diagnosis see the following Web pages:
The Primary Immunodeficiency Resource Center provides further details regarding diagnosis of SCID.
An article from Medscape Reference provides detailed information on the diagnosis of SCID. You may need to register to view the article, but registration is free.