This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Increased plasma triglycerides
Increased serum triglycerides
Increased triglycerides[ more ]
Decreased circulating cholesterol level
|30%-79% of people have these symptoms|
Pain in stomach
Stomach pain[ more ]
|Chronic noninfectious lymphadenopathy||0002730|
|Coronary artery stenosis||
Narrowing of coronary artery
|Distal muscle weakness||
Weakness of outermost muscles
Eyelid turned out
Enlarged liver and spleen
Poor nail formation
|Orange discoloured tonsils||0030814|
|Peripheral axonal neuropathy||0003477|
|5%-29% of people have these symptoms|
|Carotid artery stenosis||
Narrowing of carotid artery
|Impaired thermal sensitivity||0006901|
|Left ventricular hypertrophy||0001712|
Low platelet count
|Percent of people who have these symptoms is not available through HPO|
|Coronary artery atherosclerosis||
Plaque build-up in arteries supplying blood to heart
|Decreased circulating high-density lipoprotein levels||
Decreased circulating high-density lipoprotein cholesterol
Decreased HDL cholesterol
Low HDL-cholesterol[ more ]
Distal muscle wasting
|Impaired pain sensation||
Decreased pain sensation
|Impaired temperature sensation||
Abnormality of temperature sensation
Loss of temperature sensation[ more ]
|Opacification of the corneal stroma||0007759|
Increased spleen size
Loss of eyesight
Poor vision[ more ]
To reduce the risk for heart and blood vessel disease, people with this condition should maintain a low fat (especially saturated fat) diet and overall healthy lifestyle. Heart disease
To date, no treatment has been found to prevent the progression of this disease, including trials of omega-3-fatty acids, antioxidants, and vitamin E.
Individuals with Tangier disease may benefit from referral to specialized lipid centers for advanced management. Consultation with the following specialists may be required:
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Got a Great Research Idea? ‘All of Us’ Wants to Hear It!
January 18, 2018
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
Where can confirmatory testing for Tangier disease be performed? How might this condition be treated?