This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Increased plasma triglycerides
Increased serum triglycerides
Increased triglycerides[ more ]
Decreased circulating cholesterol level
|30%-79% of people have these symptoms|
Pain in stomach
Stomach pain[ more ]
|Chronic noninfectious lymphadenopathy||0002730|
|Coronary artery stenosis||
Narrowing of coronary artery
|Distal muscle weakness||
Weakness of outermost muscles
Eyelid turned out
Enlarged liver and spleen
Poor nail formation
|Orange discoloured tonsils||0030814|
|Peripheral axonal neuropathy||0003477|
|5%-29% of people have these symptoms|
Low number of red blood cells or hemoglobin
|Carotid artery stenosis||
Narrowing of carotid artery
|Impaired thermal sensitivity||0006901|
|Left ventricular hypertrophy||0001712|
Fluid-filled cyst in spinal cord
Low platelet count
|Percent of people who have these symptoms is not available through HPO|
|Coronary artery atherosclerosis||
Plaque build-up in arteries supplying blood to heart
|Decreased HDL cholesterol concentration||
Decreased circulating high-density lipoprotein cholesterol
Decreased HDL cholesterol
Low HDL-cholesterol[ more ]
Distal muscle wasting
Decreased reflex response
Decreased reflexes[ more ]
|Impaired pain sensation||
Decreased pain sensation
|Impaired temperature sensation||
Abnormality of temperature sensation
Loss of temperature sensation[ more ]
Atypical nail growth
|Opacification of the corneal stroma||0007759|
Increased spleen size
Loss of eyesight
Poor vision[ more ]
To reduce the risk for heart and blood vessel disease, people with this condition should maintain a low fat (especially saturated fat) diet and overall healthy lifestyle. Heart disease
To date, no treatment has been found to prevent the progression of this disease, including trials of omega-3-fatty acids, antioxidants, and vitamin E.
Individuals with Tangier disease may benefit from referral to specialized lipid centers for advanced management. Consultation with the following specialists may be required:
If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.
If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.
You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
The differential diagnosis includes Apolipoprotein A-I deficiency, LCAT deficiency (see these terms) and secondary causes of extremely low HDL cholesterol levels that include medications (androgenic steroids, paradoxical response to fibrates) and malignancies.
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
Where can confirmatory testing for Tangier disease be performed? How might this condition be treated?