How might trichorhinophalangeal syndrome (TRPS) affect an individual in adulthood?
Information on late onset TRPS symptoms is limited. Joint stiffness, chronic joint pain, and degenerative hip disease (e.g., Perthes-like hip disease) are thought to be relatively common in adults with TRPS. There have been a couple reports of osteopenia or osteoporosis in adults with TRPS. Life expectancy of people with TRPS is normal.
Last updated: 3/28/2016
Is trichorhinophalangeal syndrome (TRPS) associated with excessive sweating?
We were unable to find information regarding an association between TRPS and excessive sweating. One case report described a child with a fish-like malodour and TRPS. Her TRPS was due to a novel mutation in TRPS1, however the cause of the malodour was not determined. The association, if any, between the malodour and TRPS is not known.
Izumi K, Takagi M, Parikh AS, Hahn A, Miskovsky SN, Nishimura G, Torii C, Kosaki K, Hasegawa T, Neilson DE. Late manifestations of tricho-rhino-pharangeal syndrome in a patient: Expanded skeletal phenotype in adulthood. Am J Med Genet A. 2010 Aug;152A(8):2115-9; http://www.ncbi.nlm.nih.gov/pubmed/20635356.
Nakamura M, Sugita K, Tokura Y. A novel missense mutation in the TRPS1 gene in a case of trichorhinophalangeal syndrome type I (TRPS1) with fish-like malodour. J Eur Acad Dermatol Venereol. 2010 Mar;24(3):358-9; http://www.ncbi.nlm.nih.gov/pubmed/19694891. Accessed 7/22/2011.