Examples of painful bone, joint, and nerve injuries that have been described in individual patients with PPHP include:
Why complications like these sometimes happen to people with PPHP is not clear. Mutations in the gene GNAS cause PPHP. GNAS is being studied for its role in causing abnormal bone growth in soft tissues (i.e., progressive osseous heteroplasia). These GNAS effects may explain why painful tissue, joint, and nerve damage occurs in people with PPHP.
We strongly recommend that you speak with your healthcare provider regarding the symptoms you have been experiencing, and to discuss your testing and treatment options.
In addition, the following organizations provide information and support to people who live with chronic pain and may be a helpful resource.