This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Pain in stomach
Stomach pain[ more ]
Loss of developmental milestones
Mental deterioration in childhood[ more ]
Tiredness[ more ]
Swollen lymph nodes in center of chest
|30%-79% of people have these symptoms|
Low blood pressure
Muscle pain[ more ]
Inflammation of tissues lining lungs and chest
Trouble sleeping[ more ]
Increased spleen size
|5%-29% of people have these symptoms|
|Abnormal pyramidal sign||0007256|
Low number of red blood cells or hemoglobin
|Cranial nerve paralysis||0006824|
Spontaneous milk flow from breast
Too much cerebrospinal fluid in the brain
Low blood sodium levels
|Increased intracranial pressure||
Rise in pressure inside skull
Body fails to respond to insulin
Inflammation of heart muscle
Fluid accumulation in lower limbs
Lower leg swelling[ more ]
Swelling or irritation of membrane around heart
Eyeballs bulging out
Protruding eyes[ more ]
After treatment, the likely outcome for most people with Whipple disease is good. Most symptoms disappear in about 1 month. Relapse is common, however, highlighting the need to closely watch for a return of symptoms.
People with neurologic Whipple disease who relapse tend to have much poorer health outcomes, including serious neurologic symptoms and even death; therefore, some researchers argue that all cases of Whipple disease should be considered neurologic.
Prompt diagnosis is imperative, as very effective therapies are easy to employ with typically rapid limitation of
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
The differential diagnosis includes seronegative polyarthritis, ankylosing spondylitis, culture-negative endocarditis, vasculitis, malabsorption syndrome, lymphoma, cerebrovascular disease, dementia, HIV infection, atypical mycobacteriosis and sarcoidosis (see these terms).
Visit the Orphanet disease page for more information.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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