In addition to the signs and symptoms found in Wolfram syndrome type 1, people with Wolfram syndrome type 2 may also have stomach and/or intestinal ulcers; and a tendancy to bleed excessivly after injuries.
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|Sensorineural hearing impairment||0000407|
|30%-79% of people have these symptoms|
|Abnormality of mesentery morphology||0100016|
Difficulty articulating speech
Painful or difficult urination
|Feeding difficulties in infancy||0008872|
|Recurrent urinary tract infections||
Frequent urinary tract infections
Urinary tract infection
Urinary tract infections
Urinary tract infections, recurrent[ more ]
|5%-29% of people have these symptoms|
|Cerebral cortical atrophy||0002120|
Delayed pubertal development
Delayed pubertal growth
Pubertal delay[ more ]
Progressive dementia[ more ]
Loss of developmental milestones
Mental deterioration in childhood[ more ]
Sensory hallucination[ more ]
Mental retardation, nonspecific
Mental-retardation[ more ]
Stiff joints[ more ]
Decreased function of male gonad
Muscle tissue disease
Eye muscle paralysis
Trouble sleeping[ more ]
|Percent of people who have these symptoms is not available through HPO|
|Abnormality of the skeletal system||
Skeletal anomalies[ more ]
Psychiatric disturbances[ more ]
Degeneration of cerebrum
Swallowing difficulty[ more ]
Retarded growth[ more ]
|Limited mobility of proximal interphalangeal joint||
Limited mobility of innermost hinge joint
Low blood neutrophil count
Low neutrophil count[ more ]
Damaged optic nerve
Drooping upper eyelid
Low platelet count
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Got a Great Research Idea? ‘All of Us’ Wants to Hear It!
January 18, 2018
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.