How might persistent Müllerian duct syndrome be treated?
Treatment for persistent Mullerian duct syndrome (PMDS) may involve surgery to place the testes within the scrotum and to remove Müllerian structures. Treatment aims to prevent the two main complications: cancer and infertility.
Surgery to place the testes within the scrotum (orchidopexy) is recommended due to the risk of cancer otherwise. Whether to remove Müllerian structures has been controversial in the past. Authors of more recent articles have recommended removing Müllerian structures due to increasing reports of cancer, and because they can also cause discomfort and hematuria (blood in the urine). It has been suggested that surgery should be done between the ages of one and two years to reduce the risk of damaging the vas deferens. Orchidopexy and removal of Mullerian structures should be done at the same time or as a staged procedure if needed.
Some causes of infertility (whether present at birth or due to surgical treatment) may be treatable by extracting sperm from the testicles and using assisted reproductive technology (ART).
Last updated: 6/19/2017
Who should I speak with regarding treatment for persistent Müllerian duct syndrome?
People seeking treatment information about persistent Müllerian duct syndrome are encouraged to speak with a urologist (a physician who specializes in problems of the urinary tract and male reproductive organs). Your health care provider may be able to recommend a urologist in your area who may have knowledge of this condition.
Picard JY, Cate RL, Racine C, Josso N. The Persistent Müllerian Duct Syndrome: An Update Based Upon a Personal Experience of 157 Cases. Sex Dev. May 20, 2017; [Epub ahead of print]:https://www.ncbi.nlm.nih.gov/pubmed/28528332.