Muckle-Wells syndrome can have severe consequences as a result of long-term high levels of inflammation in the body. In some patients, this leads to secondary or AA amyloidosis, an abnormal accumulation of the protein amyloid in the tissues and organs. This can become life-threatening due to a permanent build-up of amyloid in the kidneys, liver, spleen, and elsewhere. The most common clinical presentation is kidney failure.
Last updated: 10/17/2011
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