is a rare bone disease that causes bony growths on the long bones, such as the thigh bone and shine bone.
Ribbing disease affects women more frequently than men. The most common symptom is pain. A single study of 14 patients found an association between Ribbing disease and impaired exercise tolerance and changes in heart function (i.e., increased prevalence of arrhythmia
and changes in left ventricular systolic and diastolic function).
The cause of the condition is currently unknown, although some cases appear to be genetic and inherited in an autosomal recessive
fashion. Optimal treatment for the disease is largely unknown. There have been case reports describing treatment of Ribbing disease with bisphosphonate pamidronate
. Results have been mixed. The condition often resolves on its own; however cases of progressive disease have been described.
Last updated: 12/1/2011