Primary orthostatic tremor

Title

Other Names:

OT; Shaky leg syndrome; Orthostatic tremor, primary; OT; Shaky leg syndrome; Orthostatic tremor, primary; POT See More

Categories:

Nervous System Diseases

Summary Summary

Primary orthostatic tremor is a movement disorder characterized by rhythmic muscle contractions that occur in the legs and trunk immediately after standing. It may be perceived more as an unsteadiness than an actual tremor. The tremor may disappear or improve when a person is sitting or walking.^[1]^[2] Over time, the tremors may become more severe, affecting quality of life and causing increasing disability.^[2]^[3] In some cases, primary orthostatic tremor may occur with other movement disorders.^[3] Individuals with primary orthostatic tremor may be treated with clonazepam and primidone.^[1] The cause of this condition is unknown.^[2]

Last updated: 3/17/2014

Symptoms Symptoms

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

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Medical Terms	Other Names	Learn More: HPO ID
80%-99% of people have these symptoms
EMG abnormality		0003457
Muscle cramps		0003394
Tremor	Tremors	0001337
30%-79% of people have these symptoms
Myalgia	Muscle ache Muscle pain [ more ]	0003326
5%-29% of people have these symptoms
Abnormality of extrapyramidal motor function		0002071

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Do you have more information about symptoms of this disease? We want to hear from you.

Last updated: 4/1/2018

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Research Research

Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.

Clinical Research Resources

ClinicalTrials.gov lists trials that are related to Primary orthostatic tremor. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Organizations Organizations

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

National Tremor Foundation (UK)
Long Term Conditions Centre
Gubbins Lane
Harold Wood
Essex
RM3 0AR
United Kingdom
Telephone: + 44 (0) 1708 386399
E-mail: tremorfoundation@aol.com
Website: http://www.tremor.org.uk/
Orthostatic Tremor - information and forum
E-mail: admin@orthostatictremor.org
Website: http://www.orthostatictremor.org/
Tremor Action Network
P.O. Box 5013
Pleasanton, CA 94566-5013
Telephone: 510-681-6565 or 925-462-0111
Fax: 925-369-0485
E-mail: info@tremoraction.org
Website: http://www.tremoraction.org

Do you know of an organization? We want to hear from you.

Learn More Learn More

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

Where to Start

The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In-Depth Information

The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
PubMed is a searchable database of medical literature and lists journal articles that discuss Primary orthostatic tremor. Click on the link to view a sample search on this topic.

News & Events News & Events

News

National DNA Day Reddit "Ask Me Anything" (AMA) Series
April 11, 2018

GARD Answers GARD Answers

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References References

Tremor Fact Sheet. National Institute of Neurological Disorders and Stroke (NINDS). February 10, 2014; http://www.ninds.nih.gov/disorders/tremor/detail_tremor.htm. Accessed 3/17/2014.
Jankovic J. Primary Orthostatic Tremor. National Organization for Rare Disorders (NORD). 2014; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1133/viewAbstract. Accessed 3/17/2014.
Mestre TA, Lang AE, Ferreira JJ, Almeida V, de Carvalho M, Miyasaki J, Chen R, Fox S. Associated movement disorders in orthostatic tremor. J Neurol Neurosurg Psychiatry. 2012; 83:725-729. http://jnnp.bmj.com/content/83/7/725.abstract. Accessed 3/17/2014.

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