Warthin tumor

Title

Other Names:

Papillary cystadenoma lymphomatosum (formerly)

Summary Summary

Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time.^[1]^[2]^[3]

Last updated: 9/8/2015

Symptoms Symptoms

Warthin tumor is a benign (noncancerous) tumor of the salivary glands. They most commonly arise in the parotid glands, the largest salivary glands which are located in each cheek above the jaw in front of the ears. Approximately 5-14% of cases are bilateral and 12-20% of affected people experience multicentric (more than one tumor which formed separately from one another) disease.^[2]^[3]

The first symptom is usually a firm, painless bump. Without treatment, the swelling may gradually increase overtime which can cause facial nerve palsy (difficulty moving one side of the face).^[1]

Last updated: 9/8/2015

Cause Cause

The exact underlying cause of Warthin tumor is currently unknown. However, smoking is thought to increase the risk of developing the tumor. Some studies suggest that radiation exposure and autoimmune disorders may also be associated with Warthin tumor.^[4]^[2]

Last updated: 9/8/2015

Diagnosis Diagnosis

A diagnosis of Warthin tumor is often suspected based on the presence of characteristic signs and symptoms. The following tests may then be ordered to confirm the diagnosis and rule out other conditions that cause similar features:^[1]^[3]

X-rays of the salivary gland (called a ptyalogram or sialogram)
CT scan, MRI and/or ultrasound
Salivary gland biopsy

Last updated: 9/8/2015

Treatment Treatment

Treatment of Warthin tumor generally includes surgery to remove the tumor or careful observation to watch for changes in the tumor over time. Because Warthin tumor is almost always benign, additional treatment (i.e. radiation therapy and/or chemotherapy) is rarely needed.^[1]^[3]

Last updated: 9/8/2015

Prognosis Prognosis

The long-term outlook for people with Warthin tumor is generally good. The tumor is almost always benign and is generally cured with surgery. The risk of recurrence (the tumor returning) is thought to be 2% or less.^[2]

Last updated: 9/8/2015

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In-Depth Information

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Benign Parotid Tumors
Benign Tumors of Major Salivary Glands
PubMed is a searchable database of medical literature and lists journal articles that discuss Warthin tumor. Click on the link to view a sample search on this topic.

News & Events News & Events

NCATS Co-Sponsored Conferences

Rare Tumors Initiative Symposium Strategies to Develop Therapies for Rare Tumors: Small Numbers, but Big Opportunities Wednesday, June 17, 2015
Location: NIH Natcher Conference Center, Bethesda, MD
Description: The goals of this symposium are to increase communication and build networks between researchers working in rare tumors across NIH, and to get input from patient groups, industry, and the FDA on how to overcome the biggest hurdles in the development of therapies for rare tumors. The Rare Tumors Initiative at NCI, CCR will use this information to prioritize goals for the future and will prepare a white paper summary to help guide researchers worldwide.

Contact: Dr. Karlyne Reilly,(301) 846-7518, reillyk@mail.nih.gov

Co-funding Institute(s): National Cancer Institute, Office of Rare Diseases Research

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I was diagnosed with Warthin tumor and was told it is a common tumor. We are going to watch and see if it keeps growing. Can this turn into cancer? See answer

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References References

Salivary Gland Tumors. MedlinePlus. February 2014; http://www.nlm.nih.gov/medlineplus/ency/article/001040.htm.
Iwai T, Baba J, Murata S, Mitsudo K, Maegawa J, Nagahama K, Tohnai I. Warthin tumor arising from the minor salivary gland. J Craniofac Surg. September 2012; 23(5):374-376.
Sanford Dubner, MD. Benign Parotid Tumors. Medscape Reference. March 2015; http://emedicine.medscape.com/article/1289560-overview#showall.
Scott A Laurie, MD, FRCPC. Salivary gland tumors: Epidemiology, diagnosis, evaluation, and staging. UpToDate. September 2013; Accessed 9/8/2015.