Atypical hemolytic-uremic syndrome differs from a more common condition called typical hemolytic-uremic syndrome. The two disorders have different causes and different signs and symptoms.
The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
|Signs and Symptoms||Approximate number of patients (when available)|
|Acute kidney injury||-|
|Autosomal dominant inheritance||-|
|Autosomal recessive inheritance||-|
|Decreased serum complement C3||-|
|Decreased serum complement factor B||-|
|Decreased serum complement factor H||-|
|Decreased serum complement factor I||-|
|Elevated serum creatinine||-|
|Increased blood urea nitrogen||-|
|Microangiopathic hemolytic anemia||-|
The resources below provide information about treatment options for this condition. If you have questions about which treatment is right for you, talk to your healthcare professional.
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My brother in law has just been diagnosed with atypical hemolytic-uremic syndrome (aHUS) and has suffered kidney failure. We have found out his cousin also has it. One of our concerns is for my husband and our two children. Is there a way that they can be tested to rule out aHUS? See answer