My husband has Klinefelter syndrome and we were hoping to go through the ICSI/IVF treatment but we wanted to know if we were successful with the pregnancy with a boy would the boy baby also have Klinefelter syndrome because the father has it?
Are people with Klinefelter syndrome able to have children?
The vast majority of people with Klinefelter syndrome (KS) are azoospermic (have no sperm present in the ejaculate). However, motile sperms in the ejaculate and even spontaneous pregnancies resulting from fathers with KS have been described, although such cases are rare. In general, people with mosaic KS (those that also have a 46,XY cell line) are less severely affected so the chance of finding sperm in the ejaculate is significantly higher than in non-mosaic cases. In the past, the use of donor semen or adoption were the only possible ways of having a child. However, in recent years, testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (ICSI) have helped more than 100 people with KS became biological parents.
People with KS should not automatically assume they are infertile without thorough testing.
Last updated: 10/13/2015
Are the children of a person with Klinefelter syndrome at increased risk to have the same condition or another chromosome abnormality?
Studies of ejaculated or testicular mature sperm in people with Klinefelter syndrome (KS) have shown varying amounts of normal sperm. It has been proposed that adults with KS have a substantially higher proportion of sperm with an abnormal number of chromosomes than those without KS, giving these people a theoretically increased risk of fathering a child with conditions such as Klinefelter syndrome or 47 XXX syndrome. It has also been proposed that affected people may have an increased risk for sperm with an extra copy of chromosome 13, 18, or 21.