The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
There is no specific treatment at this time for idiopathic hypersomnia (IH). However there are medications used to treat narcolepsy that may help some people with IH. The goal of treatment is to help the person with IH stay awake during the day. The medications include stimulants, non-stimulants, and a medication taken at night to increase deeper sleep. Regular follow-up to make certain the therapy continues to help is very important. Scheduled naps and behavioral therapy do not appear to be helpful for those with idiopathic hypersomnia.
Specifically, the medications which have been used to treat IH include modafinil, sodium oxybate, amphetamine, dextroamphetamine, methylphenidate, and selegiline. Since these medications were originally developed and approved for treating narcolepsy, they may not work as well for IH. Each of the medications also has side effects, therefore it is important to be certain the person with IH is carefully monitored by a doctor as different medications are tried. Other treatments including flumazenil (blocks GABA-A)and tiprolisant (blocks histamine) seem promising in early studies for people with IH, but to date there is no FDA approved treatment for IH.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
What methods have been used to successfully treat idiopathic hypersomnolence? Is modafinil still the preferred treatment? See answer