The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
|Signs and Symptoms||Approximate number of patients (when available)|
|Abnormality of the eyebrow||90%|
|Abnormality of the teeth||50%|
|Abnormality of the anterior chamber||7.5%|
|Abnormality of the oral cavity||7.5%|
|Abnormality of the respiratory system||7.5%|
|Inflammatory abnormality of the eye||7.5%|
|Abnormality of metabolism/homeostasis||-|
|Autosomal dominant inheritance||-|
While there is no recognized definitive treatment for monilethrix, oral acitretin and topical 2% minoxidil have shown good clinical and cosmetic results with continued use. The systemic administration of vitamins, retinoids, griseofulvin, oral contraceptives, steroids, radiation therapy, external desquamative ointments, and steroid preparations have not show impressive results.
Avoiding trauma is perhaps the most effective method of managing monilethrix. This is because from birth, the hair of individuals with monilethrix tends to have an increased susceptibility to weathering and cosmetic damage (e.g., sunlight exposure, dyeing, bleaching, perming, curling). This susceptibility to damage can prevent hair from growing to its maximum length.
Nonprofit support and advocacy groups bring together patients, families, medical professionals, and researchers. These groups often raise awareness, provide support, and develop patient-centered information. Many are the driving force behind research for better treatments and possible cures. They can direct people to research, resources, and services. Many groups also have experts who serve as medical advisors. Visit their website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD. Suggest an organization to add.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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My daughter has monilethrix. Are there any clinical trials underway for this disorder? Any stem cell research? Is there is anything out there that might help, now or in the future?
I have monilethrix. My husband and I would like to start a family but we don't want to pass on the gene responsible for this condition. Is there anything that we can do to stop this from happening? See answer
What is known about monilethrix? I was told that there isn't a cure. Is there any research being done to discover a cure? What type of treatment is currently available? See answer