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Diseases

Genetic and Rare Diseases Information Center (GARD)

Opsoclonus-myoclonus syndrome


Other Names for this Disease
  • Polymyoclonus infantile
  • Infantile polymyoclonus
  • Opsoclonus myoclonus syndrome
  • OMS
  • Kinsbourne syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Is this disease one that runs in a family, and how can a person be tested for it?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is dancing eyes-dancing feet syndrome inherited?

Dancing eyes-dancing feet syndrome is not inherited. The disorder is sporadic and occurs in people with no history of the condition in their family.
Last updated: 4/16/2014

What causes opsoclonus myoclonus syndrome?

Opsoclonus myoclonus syndrome is generally caused by the presence of a tumor (such as neuroblastoma) or a viral infection (such as influenza, Epstein-Barr, and Coxsackie B). Other causes of this condition are rare.[1][2]
Last updated: 1/27/2016

How is opsoclonus myoclonus syndrome diagnosed?

A diagnosis of opsoclonus myoclonus syndrome (OMS) is mostly based on the presence of the characteristic signs and symptoms of the condition (i.e. it is mainly a clinical diagnosis). In some cases, laboratory tests for certain antibodies and/or for abnormal white blood cells may also be performed.[2]

The diagnosis is clinical, based on the presence of 3 out of the 4 following criteria:

1) Neuroblastoma
2) Uncontrolled eye movement (opsoclonus)
3) A movement disorder with sudden muscle contractions (myoclonus) and/or incoordination (ataxia), and
4) Behavioural and/or sleep disturbance.

In adults with OMS, a blood exam may show Hu anti-neuronal nuclear antibodies (anti-Hu) but not in children. The most efficient methods for detecting a neuroblastoma (which is present in many affected people) are MRI with contrast, and/or helical (or spiral) CT scanning.[3]
Last updated: 1/27/2016

References
Other Names for this Disease
  • Polymyoclonus infantile
  • Infantile polymyoclonus
  • Opsoclonus myoclonus syndrome
  • OMS
  • Kinsbourne syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.