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Diseases

Genetic and Rare Diseases Information Center (GARD)

Fuchs endothelial corneal dystrophy

*

* Not a rare disease

Other Names for this Disease
  • FECD
  • Late hereditary endothelial dystrophy
  • Endoepithelial corneal dystrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Fuchs endothelial corneal dystrophy (FECD) is an eye disease. It affects the thin layer of cells that line the back part of the cornea. This layer is called the endothelium. The disease occurs when these cells slowly start to die off. The cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea.[1] There are several forms of the disease according to the age of onset of the symptoms and the cause.

The early-onset form is very rare and is known as Fuchs endothelial corneal dystrophy 1 (or early-onset Fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the COL8A2 gene. Late-onset Fuchs endothelial corneal dystrophies are common and include:
Early in the disease, patients typically do not have symptoms. In the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. Over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. Once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases.[2]
Last updated: 2/3/2016

References

  1. Fuchs’ dystrophy. MedlinePlus. September 2, 2014; http://www.nlm.nih.gov/medlineplus/ency/article/007295.htm.
  2. Singh D. Fuchs Endothelial Dystrophy. Medscape Reference. August 19, 2014; http://emedicine.medscape.com/article/1193591-overview.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Fuchs endothelial corneal dystrophy. This website is maintained by the National Library of Medicine.
  • The John’s Hopkins Medicine Web site has an information page on Fuchs’ dystrophy. Click on the link above to view this information page.
  • The MayoClinic.com provides information about Fuchs endothelial corneal dystrophy. Click on the above link to access this information.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fuchs endothelial corneal dystrophy. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • FECD
  • Late hereditary endothelial dystrophy
  • Endoepithelial corneal dystrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.